I will try:
Step 1: Define two virtual com port cables for CAT and PTT control for each radio in the VSPE program.
Step 2: Define audio cables for each radio in the VAC Control program.
Step 3: Start two intances of ExpertSDR2 and make sure that each radio is connected with separate IP adresses i.e. 192.168.0.195 port 50001 and 192.168.0.197 port 50003
Step 4: Star logging program in SO2R mode and define each radio CAT com port and PTT com port
In my case I have the USB Microham u2R unit for automatic switching of headphones audio and CW keying in SO2R. You can setup Digital Voice Keyer (DVK) and Winkeyer to be triggered by the logging program, mine is N1MM+ logger.
The N1MM+ controls two radios with one keyboard and one mouse in SO2R with CAT control. Remember to activate Winkeyer, DVK and OTRSP protocol in the logger setup.
I suggest you spend a week or two to really learn all the ins and out to get familiar with everything before you will succeed in a stable system.
Do you have all the hardware needed? Microham unit, antennas, antenna switches with relay control etc. etc.
You also need to measure signals for antenna separation and harmonics to ensure that you will not kill the reciever in a radio, maybee you will need extra bandpass filters.
In my case I have a very strong harmonic RFI from outside rectification in nearby installations of some kind that I have not been able to sort out yet.
My amplifier has +60 dBm output and the harmonic on the other bands by this RFI is in the order of S9+40 dB and severe pumping in cw.
I mention this just to give you an idea how much problem I have run into when trying to work SO2R at 1 kW with simple antennas in my garden.
I wish you the best of luck and look forward the have your comments when you have started with your SO2R journey!
72 de Erik SM0JCA