I am posting this info to the JTDX forum as well as Expert-Electronics.
After the release of the new JTDX I was excited to be able to use the TCI connection to ExpertSDR for the audio connection. But unfortunately this did not work on my Arch Linux computer, because I had many dropouts and crackles in the transmit signal, like before with a bad connection via audio loop.
After many unsuccessful experiments I tried to see what happens if I delay the network loopback interface (lo).
$ sudo tc qdisc add dev lo root netem delay 5ms
Unexpectedly, the two programs suddenly work together without any problems, no more dropouts, no more crashes.

I don't have an explanation for this yet, but wanted to pass along the tip in case other OMs have similar problems with it.
Furthermore, it has shown to be favorable in my case, to increase the parameter of
ExpertSDR / Options / Device / TX / Tx to Rx to 300 ms
because otherwise there are shifts in the transmission from pass to pass.
73 de Dieter, DK6OV